Differences in sex distribution between genetic and sporadic FTD

Abstract Background The reported sex distribution differs between frontotemporal dementia (FTD) cohorts. Possible explanations are the evolving clinical criteria of FTD and its subtypes discovery causal genetic mutations that have resulted in variable findings. Our aim was to determine a large international retrospective cohort sporadic FTD. Method We included patients with probable definite behavioural variant (bvFTD), non‐fluent primary progressive aphasia (nfvPPA), semantic (svPPA) right temporal (rtvFTD) from Amsterdam Dementia Cohort, Montreal Neurological Institute University Ulm Technical Munich Cohort (part German Consortium Frontotemporal Lobal Degeneration), Policlinico Milan Sydney FRONTIER Cohort. compared using χ 2 tests. Result A total 910 subjects were (56.3% male), whom 654 had bvFTD, 99 nfvPPA, 117 svPPA 40 rtvFTD. Of these, 215 equal (51.2% which did not differ significantly (57.8% male, p=0.081). In bvFTD subgroup, we found male predominance (61.6% males 52.9% group, p=0.04). No differences cases other subgroups (all p>0.05). Conclusion Differences may provide important clues for differential pathogenesis warrants further research.